| Gene Symbol | RNF182 |
| Full Name | Ring Finger Protein 182 |
| Chromosome | 6p21.1 |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | brain tissue, RNF182 has garnered significant attention for its involvement in neurodegenerative diseases, particularly Alzheimer's disease (AD) and H |
| Molecular Weight | 34 kDa |
| Amino Acids | 60 aa |
| UniProt ID | Q9Y2H9 |
| GeneCards | RNF182 |
| Human Protein Atlas | RNF182 |
| Monoubiquitination | Single ubiquitin addition, often regulating protein activity or localization |
| Polyubiquitin chains | K48-linked chains typically target proteins for proteasomal degradation, while K63-linked chains serve non-degradative functions including signaling, DNA repair, and autophagy regulation |
| Cerebellum | Present in Purkinje cells and cerebellar granule neurons |
| Substantia nigra | Dopaminergic neurons express RNF182 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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