gene

RCN1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RCN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ER calcium-binding protein involved in protein folding and APP processing in Alzheimer's disease

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🧬 Gene Info

Gene Symbol	RCN1
Function	encodes a calcium-binding protein that localizes to the endoplasmic reticulum (ER) and is a member of the CREC (calumenin-RCN-ERC) family of EF-hand proteins.
Primary Expression	various cancers:
Amino Acids	332 aa
Ensembl ID	ENSG00000100994
GeneCards	RCN1
Human Protein Atlas	RCN1
Calumenin (CALU)	Widely expressed EF-hand protein
RCN1 (Reticulocalbin 1)	Brain-enriched member
RCN2 (Reticulocalbin 2)	ESCUBE-related protein
ERC1/2 (ERC-55)	Calcium-binding proteins
Signal peptide	N-terminal targeting sequence (1-20 aa)
EF-hand domains	Six calcium-binding motifs (70-300 aa)
ER retention sequence	C-terminal KDEL motif
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RCN1 Gene (Reticulocalbin 1)

gene · 913 words

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Pathway Diagram

graph TD
    RCN1["RCN1"]
    neurodegeneration["neurodegeneration"]
    RCN1 -->|"implicated_in"| neurodegeneration
    style RCN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RCN1 in their description or question text

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