gene

RBM45

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RBM45: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

2Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for RBM45 Gene

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🧬 Gene Info

Gene Symbol	RBM45
Chromosome	2q32.1
Function	is a neuronally-expressed RNA-binding protein that has emerged as a significant player in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Primary Expression	the central nervous system, with particularly high expression in motor neurons, cortical neurons, and hippocampal pyramidal cells
Molecular Weight	46 kDa
Amino Acids	405 aa
GeneCards	RBM45
Human Protein Atlas	RBM45
Associated Diseases	neurodegeneration
Interactions	ASCT2
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RBM45 Gene

gene · 1170 words

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RBM45 Protein

protein · 1472 words

→

Pathway Diagram

graph TD
    RBM45["RBM45"]
    ASCT2["ASCT2"]
    RBM45 -->|"phosphorylates"| ASCT2
    Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    RBM45 -->|"upregulates"| Hepatocellular_Carcinoma
    neurodegeneration["neurodegeneration"]
    RBM45 -->|"implicated in"| neurodegeneration
    style RBM45 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (2)

Target	Relation	Type	Str
ASCT2	phosphorylates	protein	0.80
Hepatocellular Carcinoma	upregulates	disease	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RBM45 in their description or question text

No additional research found