Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RAB38 |
| Full Name | RAB38, Member RAS Oncogene Family |
| Chromosome | 11q14.2 |
| Function | RAB38 encodes a small GTPase involved in intracellular vesicle trafficking, particularly melanosome and lysosome-related organelle function. |
| Molecular Weight | 25 kDa |
| UniProt ID | [O14964](https://www.uniprot.org/uniprot/O14964) |
| Ensembl ID | ENSG00000123892 |
| OMIM | 606436 |
| GeneCards | RAB38 |
| Human Protein Atlas | RAB38 |
| GTPase-Activating Proteins (GAPs) | Accelerate GTP hydrolysis, inactivating RAB38 |
| GDP Dissociation Inhibitors (GDIs) | Extract RAB38-GDP from membranes for cytosolic storage |
| Hermansky-Pudlak Syndrome | RAB38 mutations cause HPS, characterized by oculocutaneous albinism and bleeding diathesis. While primarily a pigment disorder, some HPS subtypes involve neurodegeneration. |
| Alzheimer's Disease | Altered RAB38 expression has been reported in AD brains, potentially affecting amyloid precursor protein (APP) trafficking and Aβ secretion. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB38["RAB38"]
neurodegeneration["neurodegeneration"]
RAB38 -->|"implicated_in"| neurodegeneration
style RAB38 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB38 in their description or question text
No additional research found