| Gene Symbol | RAB38 |
| Full Name | RAB38, Member RAS Oncogene Family |
| Chromosome | 11q14.2 |
| Function | RAB38 encodes a small GTPase involved in intracellular vesicle trafficking, particularly melanosome and lysosome-related organelle function. |
| Molecular Weight | 25 kDa |
| UniProt ID | [O14964](https://www.uniprot.org/uniprot/O14964) |
| Ensembl ID | ENSG00000123892 |
| OMIM | 606436 |
| GeneCards | RAB38 |
| Human Protein Atlas | RAB38 |
| GTPase-Activating Proteins (GAPs) | Accelerate GTP hydrolysis, inactivating RAB38 |
| GDP Dissociation Inhibitors (GDIs) | Extract RAB38-GDP from membranes for cytosolic storage |
| Hermansky-Pudlak Syndrome | RAB38 mutations cause HPS, characterized by oculocutaneous albinism and bleeding diathesis. While primarily a pigment disorder, some HPS subtypes involve neurodegeneration. |
| Alzheimer's Disease | Altered RAB38 expression has been reported in AD brains, potentially affecting amyloid precursor protein (APP) trafficking and Aβ secretion. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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