Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Phagosome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer Disease | associated_with | disease | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.85 |
| Neurodegeneration | involved_in | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Lysosomes | interacts_with | cell_type | 0.85 |
| lysosomal hydrolytic enzymes | interacts_with | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.734 | neurodegeneration | What molecular mechanisms link elevated |
| Autophagosome Maturation Checkpoint Control | 0.709 | neurodegeneration | Autophagy-lysosome pathway convergence a |
| Axonal Transport Defect: C9orf72 hexanucleotide expansion im | 0.660 | neurodegeneration | What are the neuron-specific effects of |
| Autophagosome-Lysosome Fusion Defects as Primary Driver of α | 0.630 | neurodegeneration | Gap 006 analysis (archived stub) |
| Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin- | 0.600 | neurodegeneration | What are the neuron-specific effects of |
| TFEB-Mediated Autophagosome-Lysosome Fusion Enhancement in A | 0.000 | proteomics | Quantitative proteomics of the aging syn |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Macroautophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Validate Mitochondria-Lysosome Contact Site Dysfunction in PD | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276] | Voicu V, Toader C, Șerban M, Covache-Bus | Biomedicines | 2025 | 1 |
| Acetylation in the regulation of autophagy. [PMID:35435793] | Xu Y, Wan W | Autophagy | 2023 | 1 |
| New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PMID:32924745] | Tian X, Teng J, Chen J | Autophagy | 2021 | 1 |
| Autophagosomes form at ER-mitochondria contact sites. [PMID:23455425] | Hamasaki M, Furuta N, Matsuda A, Nezu A, | Nature | 2013 | 1 |
| SNX16 functions as a nutrient-sensitive regulator of autophagosomal components r [PMID:41593027] | Que H, Rong Y | Autophagy | 2026 | 0 |
| Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in [PMID:41630123] | Deng H, Zheng S, Li M, Zhang D, Yang T, | Medicine and science in sports | 2026 | 0 |
| Rapid optogenetic manipulation of autophagy reveals that the nuclear pore comple [PMID:41676542] | Mondal P, Cyril A, Parham L, Mamriev D, | bioRxiv : the preprint server | 2026 | 0 |
| NK cell-derived GZMB (granzyme B) suppresses glioblastoma radioresistance by blo [PMID:41378763] | Yan J, Feng R, Qin Q, Shen G, Tian M, Li | Autophagy | 2026 | 0 |
| Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-medi [PMID:40327696] | ["Dash B", "Urano Y", "Mita Y", "Ashida | Proceedings of the National Ac | 2025 | 0 |
| CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosom [PMID:41413248] | Yang J, Liao C, Liang X, Ke Y, Sun Y, Hu | Cell death and differentiation | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pat [PMID:33632058] | ["Beckers J", "Tharkeshwar A", "Van Damm | Autophagy | 2021 | 0 |
| Automated Software System to Promote Anticoagulation and Reduce Stroke Risk: Clu [PMID:28119433] | ["Holt T", "Dalton A", "Marshall T", "Fa | Stroke | 2017 | 0 |
| Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (synt [PMID:24113031] | ["Heged\u0171s K", "Tak\u00e1ts S", "Kov | Autophagy | 2013 | 0 |
| Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. [PMID:23791177] | ["Buchan J", "Kolaitis R", "Taylor J", " | Cell | 2013 | 0 |
| Actinic lichen nitidus. [PMID:25386247] | ["Blalock T", "Kannan S", "Davis L"] | Dermatology reports | 2010 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Phagosome in their description or question text