Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Perforant Path Presynaptic Terminal Protection Str: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPARGC1A | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Perforant Path Presynaptic Terminal Protection Strategy | 0.696 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PGC-1α knockout effects on PV+ interneuron maturation | validation | 0.900 | 0.00 | PGC-1α knockout mice | proposed | N/A | |
| PGC-1α expression analysis during PV+ interneuron development | exploratory | 0.800 | 0.00 | mouse cortex | proposed | N/A | |
| Activity-dependent regulation of PGC-1α in PV+ interneurons | exploratory | 0.800 | 0.00 | mouse cortical neurons | proposed | N/A | |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A postnatal molecular switch drives activity-dependent maturation of parvalbumin [PMID:40669459] | Moissidis M, Abbasova L, Selten M, Alis | Cell | 2025 | 1 |
| The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. [PMID:34071270] | Mota BC, Sastre M | Int J Mol Sci | 2021 | 1 |
| Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl [PMID:33686286] | Habtemichael EN, Li DT, Camporez JP, Wes | Nat Metab | 2021 | 1 |
| Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithel [PMID:31944172] | Matsuda J, Takahashi A, Takabatake Y, Sa | Autophagy | 2020 | 1 |
| Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586] | Prashantha Kumar BR, Kumar AP, Jose JA, | Neurochem Int | 2020 | 1 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |
| Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose [PMID:41300406] | Zhang Q, Bai C, Zhang M, Yue B, Zhang J, | Biology | 2025 | 0 |
| Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: [PMID:40663938] | Ma X, Liu Y, Ding B, Liu Y, Zhang Y, Wan | Phytomedicine : international | 2025 | 0 |
| Deciphering the PGC-1α-TFAM Axis in Parkinson's Disease (PD) - A Mechanism Appro [PMID:41454214] | Iyer M, Kinoshita M, Reddy DH, Babu HWS, | Molecular neurobiology | 2025 | 0 |
| Cardioprotective effects of the jiming formula on myocardial metabolism in Mice [PMID:40220403] | Fan X, Wei X, Wang W, Chai W, Xiao J, Ha | Phytomedicine : international | 2025 | 0 |
| Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 path [PMID:40646155] | ["Yang C", "Yu H", "Zhou L", "Su H", "Li | Scientific reports | 2025 | 0 |
| Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 [PMID:37989471] | ["Guo B", "Zheng C", "Cao J", "Luo F", " | Journal of advanced research | 2024 | 0 |
| Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG [PMID:27102200] | ["Kopp T", "Jensen D", "Ravn-Haren G", " | BMC cancer | 2016 | 0 |
| Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene [PMID:18954260] | ["Mallon P", "Sedwell R", "Rogers G", "N | The Journal of infectious dise | 2008 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Perforant Path Presynaptic Terminal Protection Str in their description or question text
No additional research found