gene

PTPS

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PTPS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	PTPS
Full Name	6-Pyruvoyl-Tetrahydropterin Synthase
Chromosome	11q22.2
Function	BH4 biosynthesis, neurotransmitter synthesis
Primary Expression	both neurons and glia, with particularly high expression in dopaminergic neurons of the substantia nigra pars compacta[@lanz2008]
Amino Acids	145 aa
Exons	6
UniProt ID	Q16473
Ensembl ID	ENSG00000132932
GeneCards	PTPS
Human Protein Atlas	PTPS
Brain	Substantia nigra, striatum, hippocampus, cortex
Liver	Primary site of BH4 biosynthesis
Adrenal glands	High catecholamine synthesis
Kidney	Tetrahydrobiopterin metabolism
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PTPS — AlphaFold Q16473 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PTS Gene (6-Pyruvoyl-Tetrahydropterin Synthase)

gene · 1450 words

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Pathway Diagram

graph TD
    PTPS["PTPS"]
    neurodegeneration["neurodegeneration"]
    PTPS -->|"implicated_in"| neurodegeneration
    style PTPS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PTPS in their description or question text

No additional research found