gene

PSMA2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PSMA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PSMA2 Gene

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🧬 Gene Info

Gene Symbol	PSMA2
Full Name	Proteasome Subunit Alpha 2
Chromosome	7p14.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
UniProt ID	PSMA2
NCBI Gene ID	5683
Ensembl ID	ENSG00000146576
OMIM	176842
GeneCards	PSMA2
Human Protein Atlas	PSMA2
N-terminal domain	Forms the substrate entry portal; contains the HbYX motif critical for 19S regulatory particle binding
Core domain	Seven α-helices arranged in a barrel-like structure
Binding interface	Forms contacts with adjacent α subunits (PSMA1, PSMA5, PSMA7) in the alpha ring
Synaptic protein turnover	Rapid degradation of synaptic proteins for plasticity
Neuroprotection	Clearance of toxic protein aggregates
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSMA2 Gene

gene · 658 words

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PSMA2 Protein

protein · 788 words

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Pathway Diagram

graph TD
    PSMA2["PSMA2"]
    neurodegeneration["neurodegeneration"]
    PSMA2 -->|"implicated_in"| neurodegeneration
    style PSMA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PSMA2 in their description or question text

No additional research found