gene

PROS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

2Outgoing

1Incoming

0Experiments

0Debates

Summary

PROS1 encodes Protein S, a vitamin K-dependent anticoagulation cofactor and ligand for TAM receptor tyrosine kinases, with roles in neuroprotection, phagocytosis of apoptotic cells, and implicated in Alzheimer's disease.

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🧬 Gene Info

Gene Symbol	PROS1
Full Name	Protein S (Vitamin K-Dependent Protein S)
Chromosome	3q11.2
Function	encodes a vitamin K-dependent plasma protein that plays essential roles in both coagulation regulation and cellular signaling[@dahlback2007].
Primary Expression	excitatory and inhibitory neurons throughout the brain, with particularly high levels in the hippocampus and cerebral cortex
Molecular Weight	70 kDa
Amino Acids	676 aa
Exons	15
GeneCards	PROS1
Human Protein Atlas	PROS1
Gla domain	N-terminal γ-carboxylated glutamate residues that mediate calcium-dependent membrane binding
Thrombospondin type I repeats (TSR)	Multiple repeats that mediate protein-protein interactions
C-terminal lectin-like domain	Mediates interaction with TAM receptors
Associated Diseases	Alzheimer's disease
Interactions	AXL
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PROS1 — Protein S (Vitamin K-Dependent Protein S)

gene · 1540 words

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Pathway Diagram

graph TD
    PROS1["PROS1"]
    neurodegeneration["neurodegeneration"]
    PROS1 -->|"implicated_in"| neurodegeneration
    style PROS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
MICROGLIA	activates	cell_type	0.65
MACROPHAGES	produces	cell_type	0.65

Incoming (1)

Source	Relation	Type	Str
AXL	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROS1 in their description or question text

No additional research found