protein

PRESENILIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRESENILIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	PRESENILIN2
Protein Family	Presenilin family, aspartyl proteases
Protein Type	Protease
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	50 kDa
UniProt ID	O00287
GeneCards	PRESENILIN2
Human Protein Atlas	PRESENILIN2
Nine transmembrane domains	Spanning the membrane
Aspartyl protease motif	Two conserved aspartate residues (D257, D263) in transmembrane domains 6 and 7
Large hydrophilic loop	Between transmembrane domains 6 and 7
Amyloid Precursor Protein (APP)	Generates Aβ peptides
Notch receptors	Essential for development
E-cadherin	Cell adhesion
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PRESENILIN2 — AlphaFold O00287 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Presenilin-2 (PS2)

protein · 2003 words

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Pathway Diagram

graph TD
    PRESENILIN2["PRESENILIN2"]
    neurodegeneration["neurodegeneration"]
    PRESENILIN2 -->|"implicated_in"| neurodegeneration
    style PRESENILIN2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRESENILIN2 in their description or question text

No additional research found