protein

POLD1_PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about POLD1_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

POLD1 Protein

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🔬 Protein Info

Gene Symbol	POLD1-PROTEIN
Aliases	POLD1_PROTEIN
Function	is a heterotrimer consisting of POLD1 (catalytic subunit), POLD2 (regulatory subunit), and POLD3 (accessory subunit).
Subcellular Localization	Nucleus (replication foci), Mitochondria
Molecular Weight	~124 kDa
GeneCards	POLD1-PROTEIN
Human Protein Atlas	POLD1-PROTEIN
DNA polymerase activity	Synthesizes DNA in the 5' to 3' direction using dNTPs
3' → 5' exonuclease activity	Provides proofreading capability for high-fidelity replication
5' → 5' exonuclease activity	Processes Okazaki fragments during lagging strand synthesis
strand displacement activity	Involved in long-patch DNA repair
N-terminal domain	Contains the proofreading exonuclease domain (POLD1 residues 1-327)
C-terminal domain	Contains the polymerase active site (POLD1 residues 328-1107)
PIP box motif	PCNA-interacting peptide for processive DNA synthesis
金属离子结合位点	Conserved aspartate residues coordinate Mg²⁺ ions for catalysis
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

POLD1 Protein

protein · 1061 words

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Pathway Diagram

graph TD
    POLD1_PROTEIN["POLD1_PROTEIN"]
    neurodegeneration["neurodegeneration"]
    POLD1_PROTEIN -->|"implicated_in"| neurodegeneration
    style POLD1_PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning POLD1_PROTEIN in their description or question text

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