Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGC-1α / mitochondrial biogenesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Perforant Path Presynaptic Terminal Protection Strategy | 0.696 | neurodegeneration | Selective vulnerability of entorhinal co |
| Ancestry-Adapted Mitochondrial Rescue Therapy | 0.564 | neurodegeneration | How do neurodegeneration gene expression |
| Digital Twin-Guided Metabolic Reprogramming | 0.550 | neurodegeneration | Digital biomarkers and AI-driven early d |
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.503 | translational neuroscience | Which metabolic biomarkers can distingui |
| PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi | 0.455 | neurodegeneration | Why does PRKN-mediated mitophagy, typica |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PGC-1α knockout effects on PV+ interneuron maturation | validation | 0.900 | 0.00 | PGC-1α knockout mice | proposed | N/A | |
| PGC-1α expression analysis during PV+ interneuron development | exploratory | 0.800 | 0.00 | mouse cortex | proposed | N/A | |
| Activity-dependent regulation of PGC-1α in PV+ interneurons | exploratory | 0.800 | 0.00 | mouse cortical neurons | proposed | N/A | |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | completed | $100,000 |
| Animal Model Comparison for Neurodegenerative Disease Therapeutics | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lifestyle Intervention Mechanisms in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $430,000 |
| Metabolic Syndrome-Parkinson's Disease Axis Clinical Trial | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Parkinson's Disease Subtype Classification — Precision Medicine Approa | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Metformin restores mitochondrial bioenergetics and redox homeostasis through mod [PMID:40327990] | Brondani M, Ribeiro RT, Pinheiro CV, Hof | Biomed Pharmacother | 2025 | 1 |
| System biology-based assessment of the molecular mechanism of epigallocatechin g [PMID:40664965] | Fanai HL, Chand J, Ahmad SF, Attia SM, E | Sci Rep | 2025 | 1 |
| A postnatal molecular switch drives activity-dependent maturation of parvalbumin [PMID:40669459] | Moissidis M, Abbasova L, Selten M, Alis | Cell | 2025 | 1 |
| The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. [PMID:34071270] | Mota BC, Sastre M | Int J Mol Sci | 2021 | 1 |
| Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl [PMID:33686286] | Habtemichael EN, Li DT, Camporez JP, Wes | Nat Metab | 2021 | 1 |
| Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithel [PMID:31944172] | Matsuda J, Takahashi A, Takabatake Y, Sa | Autophagy | 2020 | 1 |
| Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586] | Prashantha Kumar BR, Kumar AP, Jose JA, | Neurochem Int | 2020 | 1 |
| The pharmacogenetics of type 2 diabetes: a systematic review. [PMID:24558078] | Nisa M Maruthur, Matthew O Gribble, Wend | Diabetes care | 2014 | 1 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |
| PSMD4 Alleviates Aβ₁₋₄₂-Induced Mitochondrial Dysfunction and Oxidative Stress v [PMID:41269417] | Yuan M, Han XJ, Luo CQ, Pan HL, Zhou HY | Mol Neurobiol | 2025 | 0 |
| Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose [PMID:41300406] | Zhang Q, Bai C, Zhang M, Yue B, Zhang J, | Biology | 2025 | 0 |
| p75NTR Modulation by LM11A-31 Counteracts Oxidative Stress and Cholesterol Dysme [PMID:41045381] | ["Pensabene D", "Martella N", "Scavo G", | Neurochemical research | 2025 | 0 |
| PSMD4 Alleviates Aβ₁₋₄₂-Induced Mitochondrial Dysfunction and Oxidative Stress v [PMID:41269417] | ["Yuan M", "Han X", "Luo C", "Pan H", "Z | Molecular neurobiology | 2025 | 0 |
| Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: [PMID:40663938] | Ma X, Liu Y, Ding B, Liu Y, Zhang Y, Wan | Phytomedicine : international | 2025 | 0 |
| Lipid metabolism and immune crosstalk in fish gut-liver axis: Insights from SOCS [PMID:40914506] | Altaf F, Wu N, Shi M, Li J, Shan J, Su L | Fish & shellfish immunology | 2025 | 0 |
| Deciphering the PGC-1α-TFAM Axis in Parkinson's Disease (PD) - A Mechanism Appro [PMID:41454214] | Iyer M, Kinoshita M, Reddy DH, Babu HWS, | Molecular neurobiology | 2025 | 0 |
| Cardioprotective effects of the jiming formula on myocardial metabolism in Mice [PMID:40220403] | Fan X, Wei X, Wang W, Chai W, Xiao J, Ha | Phytomedicine : international | 2025 | 0 |
| Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 path [PMID:40646155] | ["Yang C", "Yu H", "Zhou L", "Su H", "Li | Scientific reports | 2025 | 0 |
| Cordycepin Modulates Microglial M2 Polarization Coupled with Mitochondrial Metab [PMID:38889331] | ["Zhong X", "Gong S", "Meng L", "Yao W", | Advanced science (Weinheim, Ba | 2024 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning PGC-1α / mitochondrial biogenesis in their description or question text
No additional research found