gene

PEX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PEX6 (Peroxisome Biogenesis Factor 6) gene encodes a peroxin ATPase essential for peroxisome biogenesis and peroxisomal matrix protein import. Mutations cause peroxisome biogenesis disorders and complementation group 6 (CG6).

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🧬 Gene Info

Gene Symbol	PEX6
Aliases	Peroxisome Biogenesis Factor 6, Page for PEX6 Protein
Chromosome	6p21.1
Protein Type	Gene
Function	PEX6, in complex with PEX1 (another AAA ATPase), extracts PEX5 from the peroxisomal membrane.
Molecular Weight	104 kDa
Amino Acids	979 aa
Exons	13
GeneCards	PEX6
Human Protein Atlas	PEX6
ATP Binding	PEX6 binds ATP in its AAA domains
Conformational Changes	ATP hydrolysis drives conformational changes in the hexamer
PEX5 Extraction	These conformational changes pull ubiquitinated PEX5 from the membrane
ATP Hydrolysis	Hydrolysis of ATP releases PEX6 for another cycle
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PEX6 Gene

gene · 2762 words

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PEX6 Protein - Peroxisome Biogenesis Factor 6

protein · 1118 words

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Pathway Diagram

graph TD
    PEX6["PEX6"]
    neurodegeneration["neurodegeneration"]
    PEX6 -->|"implicated_in"| neurodegeneration
    style PEX6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PEX6 in their description or question text

No additional research found