gene

PEX2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PEX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PEX2 (Peroxisome Biogenesis Factor 2) gene encodes a peroxin essential for peroxisome biogenesis and peroxisomal matrix protein import. Mutations cause peroxisome biogenesis disorders including Zellweger syndrome.

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🧬 Gene Info

Gene Symbol	PEX2
Aliases	Peroxisome Biogenesis Factor 2, Page for PEX2 Protein
Chromosome	8q21.13
Protein Type	Gene
Function	It recognizes signal sequences in PMPs and facilitates their proper insertion.
Molecular Weight	33 kDa
Amino Acids	299 aa
Exons	4
GeneCards	PEX2
Human Protein Atlas	PEX2
Ubiquitination	PEX2 is ubiquitinated on its cytosolic domains, targeting it for recycling or degradation
Phosphorylation	Serine/threonine phosphorylation may regulate PEX2 function and interactions
N-myristoylation	Some evidence suggests potential myristoylation at the N-terminus
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PEX2["PEX2"]
    neurodegeneration["neurodegeneration"]
    PEX2 -->|"implicated_in"| neurodegeneration
    style PEX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PEX2 in their description or question text

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