Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDK1, PFKFB3, LDHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| SNCA | co_associated_with | gene | 0.40 |
| WNT3A, CTNNB1, TCF7L2 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | co_associated_with | gene | 0.40 |
| IL1A, TNF, C1Q | co_associated_with | gene | 0.40 |
| CST, GAL3ST1 | co_associated_with | gene | 0.40 |
| DAP12, SYK, PLCG2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Oligodendrocyte Progenitor Cell Metabolic Reprogramming | 0.486 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 6 hypotheses Top: 0.682
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PDK1, PFKFB3, LDHA in their description or question text
No additional research found