Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1A, TNF, C1Q: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.50 |
| SNCA | co_associated_with | gene | 0.40 |
| WNT3A, CTNNB1, TCF7L2 | co_associated_with | gene | 0.40 |
| PDK1, PFKFB3, LDHA | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | co_associated_with | gene | 0.40 |
| CST, GAL3ST1 | co_associated_with | gene | 0.40 |
| DAP12, SYK, PLCG2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte-Microglia Communication Rebalancing via Cytokine M | 0.655 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 6 hypotheses Top: 0.682
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| LPS-induced mouse model of depression with synaptic loss analysis | validation | depression | 0.900 | 0.00 | LPS-treated mice | proposed | N/A |
| Network pharmacology analysis of QTJD active compounds and pathways | exploratory | Mycoplasma pneumoniae pneumoni | 0.900 | 0.00 | computational network analysis | proposed | N/A |
| Bidirectional Mendelian randomization analysis of C1Q and ischemic str | exploratory | Ischemic stroke, Atheroscleros | 0.900 | 0.00 | Human genetic association data | proposed | N/A |
| Bidirectional Mendelian randomization analysis of C1Q and ischemic str | exploratory | Ischemic stroke (large artery | 0.900 | 0.00 | human genetic data | proposed | N/A |
| C1q neutralizing antibody intervention in depression model | validation | depression | 0.850 | 0.00 | LPS-treated mice with C1q anti | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning IL1A, TNF, C1Q in their description or question text
No additional research found