concept

PDCD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDCD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

10Outgoing

6Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PDCD1
Key Genes/Proteins	B7S1, CD274, HLA, IL1B
Related Diseases	T cell exhaustion, T Cell Exhaustion

Wiki Pages (1)

Knowledge base pages for this entity

PDCD10 Gene (Programmed Cell Death 10)

gene · 2983 words

→

Pathway Diagram

graph TD
    PDCD1[PDCD1]
    PDCD1 -->|regulates| CD8__T_cell_exhaustion[CD8+ T cell exhaustion]
    PDCD1 -->|regulates| Immune_Homeostasis[Immune Homeostasis]
    PDCD1 -->|causes| T_Cell_Exhaustion[T Cell Exhaustion]
    PDCD1 -->|expressed in| T_PEX_cell[T_PEX cell]
    PDCD1 -->|involved_in| immune_homeostasis[immune homeostasis]
    PDCD1 -->|inhibits| antitumor_immunity[antitumor immunity]
    PDCD1 -->|expressed in| CD8__T_Cell[CD8+ T Cell]
    PDCD1 -->|promotes| T_cell_exhaustion[T cell exhaustion]
    PDCD1 -->|expressed in| ILC1[ILC1]
    PDCD1 -->|expressed in| macrophages[macrophages]
    CD274[CD274] -->|binds| PDCD1
    Nivolumab[Nivolumab] -->|targets| PDCD1
    Pembrolizumab[Pembrolizumab] -->|targets| PDCD1
    B7S1[B7S1] -->|co_expressed_with| PDCD1
    IL1B[IL1B] -->|interacts| PDCD1
    HLA[HLA] -->|interacts| PDCD1

Outgoing (10)

Target	Relation	Type	Str
CD8+ T cell exhaustion	regulates	process	0.95
T_PEX cell	expressed_in	cell_type	0.90
Immune Homeostasis	regulates	process	0.90
T Cell Exhaustion	causes	phenotype	0.90
immune homeostasis	involved_in	process	0.90
antitumor immunity	inhibits	process	0.88
CD8+ T Cell	expressed_in	cell_type	0.85
T cell exhaustion	promotes	phenotype	0.85
ILC1	expressed_in	cell_type	0.80
macrophages	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
CD274	binds	gene	0.95
Nivolumab	targets	drug	0.90
Pembrolizumab	targets	drug	0.90
B7S1	co_expressed_with	protein	0.80
IL1B	interacts_with	gene	0.60
HLA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDCD1 in their description or question text

No additional research found