protein

P67775

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P67775: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PP2A Protein (Protein Phosphatase 2A)

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🔬 Protein Info

Gene Symbol	P67775
Aliases	PP2A
Protein Family	Ser/Thr Phosphatase family
Protein Type	Serine/Threonine Phosphatase
Function	is a major serine/threonine phosphatase that accounts for the majority of cellular phosphatase activity in eukaryotes.
Primary Expression	Ubiquitous, high in brain
Subcellular Localization	Cytoplasm, nucleus, synapses
Molecular Weight	~36 kDa (catalytic subunit)
UniProt ID	[P67775](https://www.uniprot.org/uniprot/P67775)
GeneCards	P67775
Human Protein Atlas	P67775
Metal-binding motif	Two metal ions (typically Fe²⁺ and Zn²⁺) coordinated by conserved residues in the active site
Active site pocket	Contains the signature motif GDYGHG (residues 124-129)
C-terminal tail	Contains a mobile region involved in regulatory interactions
B (PPP2R2A)	Neuronal isoform, enriched in brain
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PP2A Protein (Protein Phosphatase 2A)

protein · 1322 words

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Pathway Diagram

graph TD
    P67775["P67775"]
    neurodegeneration["neurodegeneration"]
    P67775 -->|"implicated_in"| neurodegeneration
    style P67775 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning P67775 in their description or question text

No additional research found