protein

P19589

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P19589: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
0Hypotheses
0Analyses
0Outgoing
2Incoming
0Experiments
0Debates

Summary

PKR Protein (Protein Kinase R)

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🔬 Protein Info
Gene SymbolP19589
Protein FamilySerine/Threonine Kinase (PKR family)
Protein TypeKinase
Functionis a serine/threonine protein kinase that plays a central role in the cellular stress response, particularly in antiviral defense and translational control[@b愛德华茲2020].
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight~62 kDa
UniProt IDP19589
GeneCardsP19589
Human Protein AtlasP19589
Zinc finger domainInvolved in protein-protein interactions
Regulatory motifsControl kinase activation
Kinase subdomain XIContains the catalytic site
Activation loopPhosphorylation site (Thr446)
ATP-binding pocketTarget of small molecule inhibitors
Associated Diseasesneurodegeneration
KG Connections2 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: P19589 — AlphaFold P19589 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PKR Protein (Protein Kinase R)

protein · 985 words

Pathway Diagram

graph TD
    P19589["P19589"]
    neurodegeneration["neurodegeneration"]
    P19589 -->|"implicated in"| neurodegeneration
    TREM2["TREM2"]
    TREM2 -->|"associated with"| P19589
    CAPN6["CAPN6"]
    CAPN6 -->|"associated with"| P19589
    style P19589 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (2)

SourceRelationTypeStr
TREM2associated_withgene0.80
CAPN6associated_withgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P19589 in their description or question text

No additional research found