Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P19589: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | P19589 |
| Protein Family | Serine/Threonine Kinase (PKR family) |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase that plays a central role in the cellular stress response, particularly in antiviral defense and translational control[@b愛德华茲2020]. |
| Primary Expression | Ubiquitous, high in brain |
| Subcellular Localization | Cytoplasm, nucleus |
| Molecular Weight | ~62 kDa |
| UniProt ID | P19589 |
| GeneCards | P19589 |
| Human Protein Atlas | P19589 |
| Zinc finger domain | Involved in protein-protein interactions |
| Regulatory motifs | Control kinase activation |
| Kinase subdomain XI | Contains the catalytic site |
| Activation loop | Phosphorylation site (Thr446) |
| ATP-binding pocket | Target of small molecule inhibitors |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
P19589["P19589"]
neurodegeneration["neurodegeneration"]
P19589 -->|"implicated in"| neurodegeneration
TREM2["TREM2"]
TREM2 -->|"associated with"| P19589
CAPN6["CAPN6"]
CAPN6 -->|"associated with"| P19589
style P19589 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning P19589 in their description or question text
No additional research found