Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Nucleolar Stress: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Apoptotic Cell Death | causes | process | 0.95 |
| apoptosis | associated_with | process | 0.90 |
| Apoptosis | associated_with | process | 0.90 |
| ribosomal proteins | causes_accumulation_of | protein | 0.80 |
| cancer | involved_in | disease | 0.75 |
| apoptosis | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rrna Processing Disruption | associated_with | process | 0.90 |
| RNA polymerase I inhibitors | targets | drug | 0.80 |
| ribosome biogenesis | regulates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Nucleolar Stress Response Normalization | 0.653 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| NPM1-IRF1 protein interaction validation | exploratory | cancer | 0.900 | 0.00 | cultured cells | proposed | N/A |
| NPM1 knockout tumor progression study in syngeneic mice | validation | cancer | 0.900 | 0.00 | syngeneic mice with subcutaneo | proposed | N/A |
| In vitro T-cell killing assay with OVA-presenting tumor cells | exploratory | cancer | 0.800 | 0.00 | OVA-presenting tumor cells and | proposed | N/A |
| DNA Damage Repair Deficiency Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | completed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629] | Wang X, Chai Y, Quan Y, Wang J, Song J, | J Hematol Oncol | 2024 | 1 |
| Significance of NPM1 Gene Mutations in AML. [PMID:34576201] | Hindley A, Catherwood MA, McMullin MF, M | Int J Mol Sci | 2021 | 1 |
| NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823] | Falini B, Brunetti L, Sportoletti P, Mar | Blood | 2020 | 1 |
| Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633] | Pfister JA, D'Mello SR | Exp Biol Med (Maywood) | 2015 | 1 |
| Functions of the histone chaperone nucleolin in diseases. [PMID:17484127] | Storck S, Shukla M, Dimitrov S, Bouvet P | Subcell Biochem | 2007 | 1 |
| Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypome [PMID:41035402] | Short NJ, Loghavi S, Yilmaz M, Karrar O, | Haematologica | 2026 | 0 |
| A Unified Model: Chromatin-Bound Multicomponent Condensates. [PMID:41481253] | Lau BK, Haarer EL, Ahn JH, Wang GG | Cancer Res | 2026 | 0 |
| Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to [PMID:41923577] | Bruzzese A, Vigna E, Martino EA, Caserta | Eur J Haematol | 2026 | 0 |
| Response to Comment on: "Prognostic implications of myelodysplasia-related gene [PMID:41924903] | Chang YS, Hou HA | Haematologica | 2026 | 0 |
| Fibrillarin: bridging ribosome biogenesis and apoptosis in cellular stress and d [PMID:41518572] | ["Zhang Z", "Zhang M", "Cao Z", "Zhao H" | Apoptosis : an international j | 2026 | 0 |
| Probing condensate microenvironments with a micropeptide killswitch. [PMID:40468084] | Zhang Y, Stöppelkamp I, Fernandez-Pernas | Nature | 2025 | 0 |
| Functions of the native NPM1 protein and its leukemic mutant. [PMID:39690184] | Falini B, Sorcini D, Perriello VM, Sport | Leukemia | 2025 | 0 |
| Spatial resolution of cellular senescence dynamics in human colorectal liver met [PMID:37157887] | ["Garbarino O", "Lambroia L", "Basso G", | Aging cell | 2023 | 0 |
| Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of [PMID:34134693] | ["Beji S", "D'Agostino M", "Gambini E", | BMC biology | 2021 | 0 |
| The nucleolus functions as a phase-separated protein quality control compartment [PMID:31296649] | Frottin F, Schueder F, Tiwary S, Gupta R | Science (New York, N.Y.) | 2019 | 0 |
| Small nucleoli are a cellular hallmark of longevity. [PMID:28853436] | ["Tiku V", "Jain C", "Raz Y", "Nakamura | Nature communications | 2017 | 0 |
| Repression of rRNA transcription by PARIS contributes to Parkinson's disease. [PMID:25315684] | ["Kang H", "Shin J"] | Neurobiology of disease | 2015 | 0 |
| How Parkinson's disease meets nucleolar stress. [PMID:24412806] | ["Parlato R", "Liss B"] | Biochimica et biophysica acta | 2014 | 0 |
| Activation of an endogenous suicide response after perturbation of rRNA synthesi [PMID:19036968] | ["Parlato R", "Kreiner G", "Erdmann G", | The Journal of neuroscience : | 2008 | 0 |
| Stress inhibits nucleocytoplasmic shuttling of heat shock protein hsc70. [PMID:15930140] | ["Kodiha M", "Chu A", "Lazrak O", "Stoch | American journal of physiology | 2005 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Nucleolar Stress in their description or question text
No additional research found