protein

NRG3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRG3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The neuregulin family consists of six structurally related proteins (NRG1-NRG6) that are characterized by an epidermal growth factor (EGF)-like domain responsible for receptor binding. NRG3 is encoded by the NRG3 gene on chromosome 10p12.

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🔬 Protein Info

Gene Symbol	NRG3PROTEIN
Chromosome	10p12.31
Function	is a member of the neuregulin family of growth factors that signal through ErbB receptor tyrosine kinases.
Primary Expression	specific neuronal populations and regulates critical developmental processes including cortical patterning, GABAergic circuit formation, myelination
Subcellular Localization	** \| Plasma membrane, secreted \|
Molecular Weight	82 kDa
Exons	20
GeneCards	NRG3PROTEIN
Human Protein Atlas	NRG3PROTEIN
Type I (HRGβ)	Contains an N-terminal immunoglobulin-like domain, followed by the EGF-like domain and a transmembrane region
Type II	Lacks the immunoglobulin domain
Type III (CRD)	Contains a cysteine-rich domain instead of the immunoglobulin domain
Associated Diseases	Alzheimer
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

nrg3-protein

protein · 2155 words

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Pathway Diagram

graph TD
    NRG3PROTEIN["NRG3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    NRG3PROTEIN -->|"implicated_in"| neurodegeneration
    style NRG3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NRG3PROTEIN in their description or question text

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