Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOVA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NOVA1 |
| Full Name | NOVA Alternative Splicing Regulator 1 |
| Chromosome | 14q12 |
| Function | encodes a neuron-specific RNA-binding protein on chromosome 14q12 that is a master regulator of alternative splicing in the nervous system. |
| Primary Expression | Neurons (hindbrain, ventral spinal cord, hippocampus, cortex) |
| Amino Acids | 512 aa |
| Exons | 8 |
| UniProt ID | P51513 |
| NCBI Gene ID | 4857 |
| Ensembl ID | ENSG00000139910 |
| OMIM | 602157 |
| GeneCards | NOVA1 |
| Human Protein Atlas | NOVA1 |
| Nuclear localization signal | Directs NOVA1 to the nucleus for co-transcriptional splicing regulation |
| Dimerization domain | NOVA1 can form homodimers and heterodimers with NOVA2 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Paraneoplastic Opsoclonus-Myoclonus Ataxia (POMA) |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NOVA1["NOVA1"]
neurodegeneration["neurodegeneration"]
NOVA1 -->|"implicated_in"| neurodegeneration
style NOVA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NOVA1 in their description or question text
No additional research found