Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | expressed_in | protein | 0.76 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | completed | $80,000 |
| Cytochrome Therapeutics | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232] | Bayati A, McPherson PS | J Biol Chem | 2024 | 1 |
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818] | Zhang J, Zeng W, Han Y, Lee WR, Liou J, | Mol Cell | 2023 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279] | Saffire H Krance, Che-Yuan Wu, Alison C | Journal of Alzheimer's disease | 2022 | 1 |
| Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641] | Zhang X, Wei M, Fan J, Yan W, Zha X, Son | Autophagy | 2021 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206] | Eskelinen EL | Mol Aspects Med | 2006 | 1 |
| Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration a [PMID:41546868] | ["Tabor G", "Litvinchuk A", "Chen Y", "A | Cell reports | 2026 | 0 |
| Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364] | Bizikova P, Matsumoto C, Ogino S, Tsukui | Vet Dermatol | 2026 | 0 |
| Measuring lysosome damage and lysophagy in vivo. [PMID:41485143] | Wu Z, Zhan H, Huang Z, Wang C, Li B et a | Autophagy | 2026 | 0 |
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675] | Luo J, Shi Y, Jiang X, Zhang B, Chen Y e | Int J Biol Macromol | 2026 | 0 |
| Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452] | Shi Y, Zhang N, Sun H, Wang Y, Zhao D et | Muscle Nerve | 2026 | 0 |
| Depalmitoylation of TEAD1 facilitates lipid droplet accumulation and resistance [PMID:40889725] | ["Sun X", "Xu S", "Ni Y", "Chen R", "Dai | Free radical biology & medicin | 2025 | 0 |
| Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling i [PMID:41256540] | ["Elbatreek M", "Li Z", "Yu X", "Gehred | bioRxiv : the preprint server | 2025 | 0 |
| AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and d [PMID:39675352] | ["Pierre L", "Juszczak F", "Delmotte V", | Autophagy | 2025 | 0 |
| Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inh [PMID:40375180] | ["Zeng Y", "Guo R", "Chen S", "Lin Y", " | Molecular medicine (Cambridge, | 2025 | 0 |
| Neurodegeneration and demyelination in multiple sclerosis. [PMID:38889714] | Garton T, Gadani SP, Gill AJ, Calabresi | Neuron | 2024 | 0 |
| STING orchestrates the neuronal inflammatory stress response in multiple scleros [PMID:38878778] | Woo MS, Mayer C, Binkle-Ladisch L, Sonne | Cell | 2024 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NAM in their description or question text
Score: 0.677 · translational neuroscience · 2026-04-16
## Mechanistic Overview Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification Biomarker starts from the claim tha
Score: 0.666 · neurodegeneration · 2026-04-02
## Mechanistic Overview Lipid Droplet Dynamics as Phenotype Switches starts from the claim that modulating DGAT1 and SOA
Score: 0.616 · neurodegeneration · 2026-04-16
## **Molecular Mechanism and Rationale** The nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway represents a
Score: 0.602 · neurodegeneration · 2026-04-17
## Mechanistic Overview NRF2-Mediated Metabolic Reprogramming: HBOT as Direct NAMPT/SIRT1 Activator for Reverse Senescen
Score: 0.592 · neurodegeneration · 2026-04-16
## Mechanistic Overview NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification starts from the
Score: 0.577 · neurodegeneration · 2026-04-20
**Molecular Mechanism and Rationale** The molecular foundation of this biomarker panel centers on the intricate interpl
Score: 0.549 · neuroinflammation · 2026-04-16
## Mechanistic Overview Combined NAMPT-Alectinib Targeting of SASP-Complement Cascade starts from the claim that modulat
Score: 0.532 · translational neuroscience · 2026-04-12
## Mechanistic Overview Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammation-Metabolism Interface Biomarker sta
Score: 0.503 · translational neuroscience · 2026-04-12
## Mechanistic Overview Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neuroprotection starts from the claim th
Score: 0.455 · neurodegeneration · 2026-04-27
Target DGAT1/DGAT2 inhibition or ATGL activation to restore metabolic homeostasis by addressing lipid metabolism dysfunc
Score: 0.400 · neurodegeneration · 2026-04-22
## Mechanistic Overview Small-Molecule Modulation of G3BP1 Condensate Dynamics via PRMT1 Methylation as a Therapeutic St
Score: 0.389 · biomarkers · 2026-04-26
This hypothesis proposes that plasma-derived exosomes carrying YKL-40, sTREM2, and neurogranin provide a superior biomar
Score: 0.380 · molecular neurobiology · 2026-04-27
The most likely explanation involves lncRNA-0021 functioning as a competitive endogenous RNA (ceRNA) that dynamically se
Score: 0.380 · biomarkers · 2026-04-27
This hypothesis proposes that exosome-derived YKL-40, sTREM2, and neurogranin from peripheral blood samples can provide