gene

NADK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NADK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

7Outgoing

0Incoming

0Experiments

0Debates

Summary

NADK Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NADK
Protein Type	Kinase
Function	NADK encodes NAD kinase, the enzyme that catalyzes NADP+ biosynthesis from NAD+.
Pathways	Mapk, Immune Response
Ensembl ID	ENSG00000008130
GeneCards	NADK
Human Protein Atlas	NADK
Antioxidant defense	NADPH provides reducing equivalents for glutathione reductase and NADPH oxidase
Biosynthetic reactions	Fatty acid synthesis, cholesterol synthesis, and nucleotide synthesis require NADPH
DNA repair	PARP activity consumes NAD+, and NADPH supports repair processes
Immune response	NADPH oxidase in phagocytic cells generates reactive oxygen species for microbial killing
Associated Diseases	neurodegeneration
Interactions	CYTOKINES, INPP5D, PROINFLAMMATORY CYTOKINES, RIPK1
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NADK Gene

gene · 2511 words

→

Pathway Diagram

graph TD
    NADK["NADK"]
    Ms{"Ms"}
    NADK -->|"activates"| Ms
    INPP5D["INPP5D"]
    NADK -->|"activates"| INPP5D
    CYTOKINES["CYTOKINES"]
    NADK -->|"activates"| CYTOKINES
    PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
    NADK -->|"activates"| PROINFLAMMATORY_CYTOKINES
    RIPK1["RIPK1"]
    NADK -->|"activates"| RIPK1
    Mapk(["Mapk"])
    NADK -->|"activates"| Mapk
    Immune_Response(["Immune Response"])
    NADK -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NADK -->|"implicated in"| neurodegeneration
    style NADK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Ms	activates	disease	0.65
CYTOKINES	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
Mapk	activates	pathway	0.60
Immune Response	activates	pathway	0.60
INPP5D	activates	gene	0.60
RIPK1	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NADK in their description or question text

No additional research found