Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial activation / TREM2 signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescent Microglia Resolution via Maresins-Senolytics Combi | 0.784 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Orexin-Microglia Modulation Therapy | 0.707 | neurodegeneration | Sleep disruption as cause and consequenc |
| Microglial Efferocytosis Enhancement via GPR32 Superagonists | 0.704 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Metabolic Reprogramming via Microglial Glycolysis Inhibition | 0.672 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: Why Does Amyloid Removal Only Slow Decline 27%? | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Microglial Aging and Immune Memory in Neurodegeneration — Training the | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Microglial Contributions to Huntington's Disease Pathogenesis | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Combination Therapy Sequencing in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Saturation mutagenesis of twenty disease-associated regulatory elements at singl [PMID:31395865] | ["Kircher M", "Xiong C", "Martin B", "Sc | Nature Communications | 2019 | 267 |
| PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305] | Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z | Mol Ther | 2026 | 1 |
| Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557] | Sun B, Zhang A, Feng S, Jamali AW, Jia Z | Int Immunopharmacol | 2026 | 1 |
| HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352] | Pesce NA, Seminara G, Giarrusso G, Tomas | Adv Biol (Weinh) | 2026 | 1 |
| Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285] | Fang M, Zhou Y, He K, Lu Y, Tao F, Huang | Mol Neurobiol | 2025 | 1 |
| Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300] | Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W | Biomed Pharmacother | 2025 | 1 |
| Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376] | Sun L, Wang X, Guan S, Zhang P, Chen D, | FASEB J | 2025 | 1 |
| Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the S [PMID:37738560] | Justice JN, Leng XI, LeBrasseur NK, Tchk | J Gerontol A Biol Sci Med Sci | 2024 | 1 |
| The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014] | Fontana F, Giannitti G, Marchesi S, Limo | Int J Biol Sci | 2024 | 1 |
| AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289] | Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh | Mol Med | 2024 | 1 |
| Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576] | Rho H, Terry AR, Chronis C, Hay N | Cell Metab | 2023 | 1 |
| The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814] | Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, | Sci Immunol | 2021 | 1 |
| Sex differences in autophagy-mediated diseases: toward precision medicine. [PMID:32264724] | Shang D, Wang L, Klionsky DJ, Cheng H, Z | Autophagy | 2021 | 1 |
| Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populatio [PMID:33144684] | He D, Wang D, Lu P, Yang N, Xue Z, Zhu X | Oncogene | 2021 | 1 |
| Low Rates of Gastrointestinal and Non-Gastrointestinal Complications for Screeni [PMID:29031502] | Wang L, Mannalithara A, Singh G, Ladabau | Gastroenterology | 2018 | 1 |
| Als and Ftd: Insights into the disease mechanisms and therapeutic targets. [PMID:29031901] | Liscic RM | Eur J Pharmacol | 2017 | 1 |
| Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling [PMID:28336668] | Castellano BM, Thelen AM, Moldavski O, F | Science | 2017 | 1 |
| Defining the consequences of genetic variation on a proteome-wide scale. [PMID:27309819] | Chick JM, Munger SC, Simecek P, Huttlin | Nature | 2016 | 1 |
| Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells [PMID:26657143] | Chang J, Wang Y, Shao L, Laberge RM, Dem | Nat Med | 2016 | 1 |
| The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. [PMID:25754370] | Zhu Y, Tchkonia T, Pirtskhalava T, Gower | Aging Cell | 2015 | 1 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Microglial activation / TREM2 signaling in their description or question text
No additional research found