Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MTR |
| Full Name | 5-Methyltetrahydrofolate-Homocysteine Methyltransferase |
| Chromosome | 1q43 |
| Protein Type | Enzyme |
| Function | is a crucial enzyme in one-carbon metabolism located in the cytoplasm of all human cells. |
| Molecular Weight | 141 kDa |
| Amino Acids | 1265 aa |
| Exons | 33 |
| UniProt ID | Q99707 |
| NCBI Gene ID | 4548 |
| Ensembl ID | ENSG00000116984 |
| OMIM | 156570 |
| GeneCards | MTR |
| Human Protein Atlas | MTR |
| Detoxification | Converts toxic homocysteine to essential methionine |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MTR["MTR"]
style MTR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
oligodendrocytes["oligodendrocytes"]
neurodegeneration["neurodegeneration"]
MTR -->|"expressed_in"| oligodendrocytes
MTR -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class oligodendrocytes mechanism
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| oligodendrocytes | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MTR in their description or question text
No additional research found