protein

MEK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MEK2 (MAP2K2) is a dual-specificity protein kinase that phosphorylates and activates ERK1/2 in the MAPK signaling cascade, playing critical roles in neuronal function and neurodegeneration.

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🔬 Protein Info

Gene Symbol	MEK2
Aliases	MAP2K2
Chromosome	19p13.3
Protein Family	MEK dual-specificity kinases
Protein Type	Kinase
Function	Active MEK2 then phosphorylates ERK1 (MAPK1/MAPK3) at specific threonine and tyrosine residues (T202/Y204 for ERK1, T185/Y187 for ERK2), enabling ERK to phosphorylate numerous downstream targets[@mapk
Molecular Weight	44.2 kDa
Amino Acids	400 aa
Pathways	MAPK, MAPK signaling
UniProt ID	[P36507](https://www.uniprot.org/uniprot/P36507)
GeneCards	MEK2
Human Protein Atlas	MEK2
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MEK2 Protein

protein · 1609 words

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MAP2K2/MEK2 Protein

protein · 749 words

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Pathway Diagram

graph TD
    MEK2["MEK2"]
    neurodegeneration["neurodegeneration"]
    MEK2 -->|"implicated_in"| neurodegeneration
    style MEK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MEK2 in their description or question text

No additional research found