gene

MAPK6

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MAPK6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MAPK6 (ERK3) is an atypical MAP kinase involved in cell division, stress responses, and synaptic plasticity. It plays roles in neurodevelopment and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	MAPK6
Full Name	Mitogen-Activated Protein Kinase 6
Protein Type	Kinase
Function	is an atypical member of the MAP kinase family.
Primary Expression	neurons and glial cells where it modulates neuronal development, cognitive function, and responses to neurotoxic stress
Subcellular Localization	**: Nuclear-cytoplasmic shuttling regulates its access to substrates
Amino Acids	721 aa
Pathways	MAPK
Ensembl ID	ENSG00000170048
GeneCards	MAPK6
Human Protein Atlas	MAPK6
Cytoskeletal dynamics	Through phosphorylation of proteins involved in actin remodeling
Stress response	Activation of p38 MAPK pathway effectors
Gene expression	Through transcription factor phosphorylation
Cell cycle progression	Regulation of G1/S transition
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAPK6 — Mitogen-Activated Protein Kinase 6

gene · 1634 words

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Pathway Diagram

graph TD
    MAPK6["MAPK6"]
    neurodegeneration["neurodegeneration"]
    MAPK6 -->|"implicated_in"| neurodegeneration
    style MAPK6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MAPK6 in their description or question text

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