gene

MAP2K7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2K7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MAP2K7 (MEK7) - Mitogen-activated protein kinase kinase 7 that specifically activates JNK1/2/3. Critical mediator of stress-activated signaling, neuronal death, and neuroinflammation. Key therapeutic target for Alzheimer's disease, Parkinson's disease, and stroke.

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🧬 Gene Info

Gene Symbol	MAP2K7
Aliases	MAP2K7 (MEK7)
Function	is a central mediator of cellular stress responses and plays critical roles in neuronal survival, synaptic plasticity, neuroinflammation, and neurodegeneration.
Subcellular Localization	and interaction partners
Amino Acids	447 aa
Pathways	pathway:[@kuan2002], MAPK
Ensembl ID	ENSG00000100030
GeneCards	MAP2K7
Human Protein Atlas	MAP2K7
Cellular stress	Oxidative stress, DNA damage, ER stress
Inflammatory cytokines	TNF-α, IL-1β, Fas ligand
Excitotoxicity	Glutamate receptor overactivation
Neurotoxic proteins	Aβ, α-synuclein, mutant huntingtin
Growth factor withdrawal	Trophic factor deprivation
JNK1 (MAPK8)	Ubiquitously expressed, JNK1a and JNK1b splice variants
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP2K7

gene · 2045 words

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Pathway Diagram

graph TD
    MAP2K7["MAP2K7"]
    neurodegeneration["neurodegeneration"]
    MAP2K7 -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    MAP2K7 -->|"implicated in"| Alzheimer_S_Disease
    Parkinson_S_Disease{"Parkinson'S Disease"}
    MAP2K7 -->|"implicated in"| Parkinson_S_Disease
    Stroke{"Stroke"}
    MAP2K7 -->|"implicated in"| Stroke
    Inflammation(["Inflammation"])
    MAP2K7 -->|"regulates"| Inflammation
    Neuroinflammation(["Neuroinflammation"])
    MAP2K7 -->|"regulates"| Neuroinflammation
    JNK["JNK"]
    MAP2K7 ---|"interacts"| JNK
    style MAP2K7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Stroke fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neuroinflammation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Inflammation fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MAP2K7 in their description or question text

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