gene

MAP2K4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2K4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MAP2K4 encodes a dual-specificity kinase that activates JNK and p38 pathways, playing critical roles in stress response, apoptosis, and neurodegeneration

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🧬 Gene Info

Gene Symbol	MAP2K4
Full Name	Mitogen-Activated Protein Kinase Kinase 4
Chromosome	17p12
Protein Type	Kinase
Function	is a dual-specificity protein kinase that serves as a critical node in cellular stress signaling.
Amino Acids	399 aa
Pathways	MAPK pathway, MAPK
UniProt ID	[P45985](https://www.uniprot.org/uniprot/P45985)
Ensembl ID	ENSG00000157873
GeneCards	MAP2K4
Human Protein Atlas	MAP2K4
N-terminal docking domain	For interaction with substrates and upstream kinases
Kinase domain	Catalytic core with dual-specificity
C-terminal regulatory region	Modulates interaction with scaffolds and localization
N-terminal D-domain	Conserved docking motif for interaction with upstream MAP3Ks and downstream MAPK substrates
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP2K4 — Mitogen-Activated Protein Kinase Kinase 4

gene · 1011 words

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Pathway Diagram

graph TD
    MAP2K4["MAP2K4"]
    neurodegeneration["neurodegeneration"]
    MAP2K4 -->|"implicated_in"| neurodegeneration
    style MAP2K4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MAP2K4 in their description or question text

No additional research found