Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LXR activation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| APOE expression | activates | phenotype | 0.90 |
| Microglia | downregulates | cell_type | 0.85 |
| Reactive Astrocytes | downregulates | cell_type | 0.85 |
| ABCA1 expression | activates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 24S-hydroxycholesterol | activates | biomarker | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
molecular biology | 2026-04-24 | 6 hypotheses Top: 0.707
neurodegeneration | 2026-04-02 | 4 hypotheses Top: 0.720
neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.852
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.58 · 2026-04-24
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
Hypotheses and analyses mentioning LXR activation in their description or question text
No additional research found