Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP1 receptor-mediated transcytosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LRP1-Dependent Tau Uptake Disruption | 0.808 | neurodegeneration | Tau propagation mechanisms and therapeut |
| Synthetic Biology BBB Endothelial Cell Reprogramming | 0.727 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Circadian-Synchronized LRP1 Pathway Activation | 0.714 | neurodegeneration | Blood-brain barrier transport mechanisms |
| LRP1-Dependent Tau Uptake Disruption | 0.600 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients | proposed | N/A |
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| HDAC4 inhibition and NHE6 expression mechanism study | exploratory | Alzheimer's disease | 0.850 | 0.00 | proposed | N/A | |
| Network Pharmacology Analysis of Shared AD Targets | exploratory | Alzheimer's disease | 0.850 | 0.00 | Computational network analysis | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| CD2AP expression and cognitive decline in AD patients | exploratory | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Blood-Based Biomarker Panel for Early AD Detection | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $220,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271] | Mushtaq T, Hameed H, Khan MA, Tariq U, H | Molecular neurobiology | 2026 | 0 |
| Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microg [PMID:41621577] | Guo H, Peng X, Zhang X, Ruganzu JB, Wu X | Experimental cell research | 2026 | 0 |
| Osteoclast-secreted galectin-3 promotes articular cartilage degeneration in OVX [PMID:40609733] | Chen L, Hong H, Yang Z, Zhong Y, Sun S e | Osteoarthritis Cartilage | 2026 | 0 |
| Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877] | Miao J, Wang J, Zhou W, Guo J | Sci Rep | 2026 | 0 |
| Lysosomal trafficking markers covering PSAP, PGRN, SORT1 and LRP1 in body liquid [PMID:41579784] | Poniatowski ŁA, Siwińska A, Acewicz A, K | Forensic science international | 2026 | 0 |
| Mitochondrial calcium uniporter knockdown in hippocampal neurons effectively att [PMID:41687804] | Wu L, Hou F, Wang Z, Wu M, Wang X, Cao J | Experimental neurology | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS m [PMID:40595262] | Sagulkoo P, Chuntakaruk H, Suratanee A, | Scientific reports | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Inhibition of tau neuronal internalization using anti-tau single domain antibodi [PMID:40175345] | ["Danis C", "Dupr\u00e9 E", "Bouillet T" | Nature communications | 2025 | 0 |
| Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial [PMID:41430102] | Gong Z, Zhang M, Liu N, Asam K, Martellu | The journal of headache and pa | 2025 | 0 |
| Ganglioside sialylation modulates tau internalization and pathology spread. [PMID:41398374] | Li S, Chen Y, Song T, Liu D, Wu R, Yang | Molecular psychiatry | 2025 | 0 |
| Microglia internalize tau monomers and fibrils using distinct receptors but simi [PMID:39713861] | Falkon KF, Danford L, Gutierrez Kuri E, | Alzheimer's & dementia : the j | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain isc [PMID:38906140] | Zhou J, Zhang L, Peng J, Zhang X, Zhang | Cell metabolism | 2024 | 0 |
| Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neuron [PMID:39554169] | Pardo E, Kim T, Wallrabe H, Zengeler KE, | bioRxiv : the preprint server | 2024 | 0 |
| The role of neutrophils in tPA thrombolysis after stroke: a malicious troublemak [PMID:39606238] | Li Q, Ye J, Li Z, Xiao Q, Tan S, Hu B, J | Frontiers in immunology | 2024 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning LRP1 receptor-mediated transcytosis in their description or question text
No additional research found