Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | LAP3 |
| Full Name | Leucine Aminopeptidase 3 |
| Aliases | Page for LAP3 |
| Function | LAP3 (Leucine Aminopeptidase 3) is a cytosolic metalloexopeptidase that hydrolyzes N-terminal amino acids from peptides and proteins. |
| Primary Expression | various cancers including glioblastoma |
| Ensembl ID | ENSG00000002587 |
| GeneCards | LAP3 |
| Human Protein Atlas | LAP3 |
| Protein Turnover | LAP3 participates in the degradation of misfolded and damaged proteins, working alongside the proteasome and lysosomal systems. |
| Antigen Processing | The enzyme generates antigenic peptides for presentation via MHC class I molecules, crucial for immune surveillance of abnormal cells. |
| Peptide Hormone Metabolism | LAP3 processes bioactive peptides including enkephalins, bradykinin, and angiotensin, modulating neuropeptide signaling in the brain. |
| Aβ peptides | Amyloid-beta fragments (1-40, 1-42) |
| α-synuclein | Toxic fragments of synuclein protein |
| Enkephalins | Endogenous opioid peptides |
| Cytokines | Pro-inflammatory peptide mediators |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LAP3["LAP3"]
neurodegeneration["neurodegeneration"]
LAP3 -->|"implicated_in"| neurodegeneration
style LAP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAP3 in their description or question text
No additional research found