Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KDM3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KDM3B |
| Full Name | Lysine Specific Demethylase 3B |
| Aliases | Page for KDM3B, Lysine Specific Demethylase 3B (JHDM2B |
| Chromosome | 5q31.1 |
| Protein Family | JHDM3/KDM3 family (Jumonji C domain demethylase) |
| Function | is a Jumonji C (JmjC) domain-containing histone demethylase that catalyzes the removal of methyl groups from histone lysine residues. |
| Primary Expression | multiple brain regions: |
| UniProt ID | Q7Z6W4 |
| NCBI Gene ID | 55693 |
| Ensembl ID | ENSG00000106479 |
| OMIM | 607395 |
| GeneCards | KDM3B |
| Human Protein Atlas | KDM3B |
| H3K9me1/2 | Primary substrate — demethylation activates gene expression |
| H3K9me3 | Also targeted, particularly in transcriptional activation |
| Associated Diseases | Childhood Interstitial Lung Disease, Litter Size, Live Lamb Number, Live Lamb Rate, Pregnancy Duration, Pulmonary Arterial Hypertension |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["KDM3B"]
N1["LMO2"]
N0 -->|"downregulates"| N1
N2["Litter Size"]
N0 -->|"associated with"| N2
N3["Pregnancy Duration"]
N0 -->|"associated with"| N3
N4["Live Lamb Number"]
N0 -->|"associated with"| N4
N5["Live Lamb Rate"]
N0 -->|"associated with"| N5
N6["Stillbirth Number"]
N0 -->|"associated with"| N6
N7["Stillbirth Rate"]
N0 -->|"associated with"| N7
N8["Pulmonary Arterial Hypertension"]
N0 -->|"associated with"| N8
N9["Childhood Interstitial Lung Disease"]
N0 -->|"associated with"| N9
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N8 disease
class N9 disease| Target | Relation | Type | Str |
|---|---|---|---|
| Stillbirth Rate | associated_with | phenotype | 0.80 |
| Stillbirth Number | associated_with | phenotype | 0.80 |
| LMO2 | downregulates | gene | 0.80 |
| Litter Size | associated_with | phenotype | 0.80 |
| Pregnancy Duration | associated_with | phenotype | 0.80 |
| Live Lamb Number | associated_with | phenotype | 0.80 |
| Live Lamb Rate | associated_with | phenotype | 0.80 |
| Pulmonary Arterial Hypertension | associated_with | disease | 0.70 |
| Childhood Interstitial Lung Disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KDM3B in their description or question text
No additional research found