Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KCNC1 |
| Full Name | Potassium Voltage-Gated Channel Subfamily C Member 1 (Kv3.1) |
| Chromosome | 11p15.5 |
| Function | Kcnc1 Gene plays an important role in the study of neurodegenerative diseases |
| Primary Expression | fast-spiking interneurons |
| Amino Acids | 512 aa |
| UniProt ID | KCNC1 |
| NCBI Gene ID | 3745 |
| Ensembl ID | ENSG00000129159 |
| OMIM | 176258 |
| GeneCards | KCNC1 |
| Human Protein Atlas | KCNC1 |
| Cortical interneurons | Parvalbumin-positive (PV+) fast-spiking interneurons in all cortical layers |
| Hippocampal interneurons | PV+ basket cells and axo-axonic cells |
| Striatal interneurons | Fast-spiking PV+ interneurons |
| Associated Diseases | neurodegeneration |
| Interactions | GABA, PVALB, SLC6A1 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNC1(["KCNC1"])
style KCNC1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
PVALB["PVALB"]
SLC6A1["SLC6A1"]
neurons["neurons"]
GABA["GABA"]
neurodegeneration["neurodegeneration"]
KCNC1 -->|"interacts_with"| PVALB
KCNC1 -->|"interacts_with"| SLC6A1
KCNC1 -->|"expressed_in"| neurons
GABA -->|"interacts_with"| KCNC1
KCNC1 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class PVALB gene
class SLC6A1 gene
class neurons mechanism
class GABA gene
class neurodegeneration disease| Source | Relation | Type | Str |
|---|---|---|---|
| proteins-kcnc1-protein | describes | wiki | 1.00 |
| GABA | interacts_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNC1 in their description or question text
No additional research found