Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KAT6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KAT6B |
| Function | The catalytic domain is located in the N-terminal region and requires acetyl-CoA as a cofactor for the acetylation reaction |
| Primary Expression | neurons and glia - Testis — High expression in spermatogonia - Bone marrow — Present in hematopoietic stem cells - Uterus — Regulated duri |
| Subcellular Localization | ### Transcriptional Co-activator Function |
| Molecular Weight | 235 kDa |
| Amino Acids | 2071 aa |
| Ensembl ID | ENSG00000138311 |
| GeneCards | KAT6B |
| Human Protein Atlas | KAT6B |
| H3K9 acetylation | Associated with transcriptionally active chromatin |
| H3K14 acetylation | Co-occurs with H3K9ac and marks active promoters |
| H4K5 acetylation | Involved in DNA replication and repair |
| N-terminal HAT domain | Catalytic activity for histone acetylation |
| Proline-rich region | Mediates protein-protein interactions |
| C-terminal domains | Include transcriptional activation domains and nuclear receptor interaction motifs |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KAT6B["KAT6B"]
neurodegeneration["neurodegeneration"]
KAT6B -->|"implicated_in"| neurodegeneration
style KAT6B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KAT6B in their description or question text
No additional research found