| Gene Symbol | KAT6B |
| Function | The catalytic domain is located in the N-terminal region and requires acetyl-CoA as a cofactor for the acetylation reaction |
| Primary Expression | neurons and glia - Testis — High expression in spermatogonia - Bone marrow — Present in hematopoietic stem cells - Uterus — Regulated duri |
| Subcellular Localization | ### Transcriptional Co-activator Function |
| Molecular Weight | 235 kDa |
| Amino Acids | 2071 aa |
| Ensembl ID | ENSG00000138311 |
| GeneCards | KAT6B |
| Human Protein Atlas | KAT6B |
| H3K9 acetylation | Associated with transcriptionally active chromatin |
| H3K14 acetylation | Co-occurs with H3K9ac and marks active promoters |
| H4K5 acetylation | Involved in DNA replication and repair |
| N-terminal HAT domain | Catalytic activity for histone acetylation |
| Proline-rich region | Mediates protein-protein interactions |
| C-terminal domains | Include transcriptional activation domains and nuclear receptor interaction motifs |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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