Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JOIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive overview of the JOIN/junctlophilin gene family, their role in neuronal calcium signaling, membrane architecture, and implications for neurodegenerative diseases including Alzheimer's and Parkinson's.
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| Gene Symbol | JOIN |
| Full Name | Junctlophilin Family Member |
| Chromosome | 17q21.31 |
| Function | is a member of the junctophilin family of membrane proteins that play critical roles in coupling intracellular calcium stores with plasma membrane calcium channels. |
| Primary Expression | multiple tissues with the highest levels in: |
| Molecular Weight | 65 kDa |
| UniProt ID | Q9HB73 |
| NCBI Gene ID | 57402 |
| Ensembl ID | ENSG00000150045 |
| OMIM | 607317 |
| GeneCards | JOIN |
| Human Protein Atlas | JOIN |
| Brain | Particularly in the cortex, hippocampus, cerebellum, and basal ganglia |
| Heart | Cardiac muscle cells (cardiomyocytes) |
| Skeletal Muscle | Skeletal muscle fibers |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
JOIN["JOIN"]
neurodegeneration["neurodegeneration"]
JOIN -->|"implicated_in"| neurodegeneration
style JOIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Seed match plus local RNA structure jointly determine lncRNA | 0.670 | molecular neurobiology | How does lncRNA-0021 achieve sequence-sp |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning JOIN in their description or question text
No additional research found