gene 2,421 words KG: JOIN
Contents

JOIN — Junctlophilin Family Member

🧬 Gene Info
Gene SymbolJOIN
Full NameJunctlophilin Family Member
Chromosome17q21.31
Functionis a member of the junctophilin family of membrane proteins that play critical roles in coupling intracellular calcium stores with plasma membrane calcium channels.
Primary Expressionmultiple tissues with the highest levels in:
Molecular Weight65 kDa
UniProt IDQ9HB73
NCBI Gene ID57402
Ensembl IDENSG00000150045
OMIM607317
GeneCardsJOIN
Human Protein AtlasJOIN
BrainParticularly in the cortex, hippocampus, cerebellum, and basal ganglia
HeartCardiac muscle cells (cardiomyocytes)
Skeletal MuscleSkeletal muscle fibers
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

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Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
PARP1 Inhibition Therapy
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
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Related Analyses (19)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (7)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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