Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INTEGRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| tumor cell proliferation | promotes | phenotype | 0.90 |
| Extracellular Matrix Stiffness | interacts_with | mechanism | 0.90 |
| Extracellular Matrix | interacts_with | compound | 0.88 |
| Cancer Cell Proliferation | activates | phenotype | 0.85 |
| cell-matrix junction | mediates | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ECM stiffness | activates | phenotype | 0.90 |
| Extracellular Matrix Stiffness | activates | mechanism | 0.85 |
| Ecm Stiffness | activates | pathway | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway | 0.580 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
| Surface Exposure of SENP1-β1 Integrin Complex Enables Target | 0.550 | neurodegeneration | How can senescent microglia be molecular |
| Downstream Pathway Selective Modulation: ITGAX (αXβ2) Integr | 0.509 | synaptic biology | Does SPP1-mediated synaptic engulfment r |
| α4β1 Integrin (VLA-4) and JAK/STAT Pathway | 0.450 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning INTEGRIN in their description or question text
No additional research found