gene

INPP4B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about INPP4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	INPP4B
Full Name	Inositol Polyphosphate-4-Phosphatase Type II
Chromosome	4q21.21
Protein Type	Phosphatase
Function	is a lipid phosphatase belonging to the inositol polyphosphate phosphatase family.
Amino Acids	656 aa
UniProt ID	[Q9NRY4](https://www.uniprot.org/uniprot/Q9NRY4)
Ensembl ID	ENSG00000040087
OMIM	607610
GeneCards	INPP4B
Human Protein Atlas	INPP4B
Metal ion-dependent catalysis	Requires Mg²⁺ or Mn²⁺
Active site residues	Cysteine nucleophile attacks the phosphate
Substrate specificity	Prefers PI(3,4)P₂ and PI(4,5)P₂
Product release	Generates PI(3)P or PI(4)P
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

INPP4B Gene — Inositol Polyphosphate-4-Phosphatase Type II

gene · 1511 words

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Pathway Diagram

graph TD
    INPP4B["INPP4B"]
    neurodegeneration["neurodegeneration"]
    INPP4B -->|"implicated_in"| neurodegeneration
    style INPP4B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning INPP4B in their description or question text

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