gene

IL27

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL27: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for IL27 Gene encoding Interleukin-27, an immunomodulatory cytokine

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🧬 Gene Info

Gene Symbol	IL27
Full Name	Interleukin 27
Chromosome	16p11.2
Protein Type	Receptor
Function	Interleukin 27 (IL-27) is a cytokine belonging to the IL-12 family that plays complex roles in immune modulation, inflammation, and neuroinflammation
Primary Expression	various tissues and cell types:
Pathways	PI3K, MAPK, JAK-STAT
UniProt ID	Q8N5L0
NCBI Gene ID	246778
Ensembl ID	ENSG00000163512
OMIM	607073
GeneCards	IL27
Human Protein Atlas	IL27
p28 (IL-27p28)	the α chain, encoded by IL27 gene
EBI3 (EBV-induced gene 3)	the β chain, shared with IL-35
Associated Diseases	neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL27 — AlphaFold Q8N5L0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL27 — Interleukin 27

gene · 2764 words

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Pathway Diagram

flowchart TD
    N0["IL27"]
    N1["Co-inhibitory Gene Module"]
    N0 -->|"activates"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway

Outgoing (3)

Target	Relation	Type	Str
co-inhibitory gene module	drives	pathway	0.95
Co-inhibitory Gene Module	activates	pathway	0.90
non-responsive T cells	regulates	cell_type	0.85

Incoming (1)

Source	Relation	Type	Str
ADORA2A	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL27 in their description or question text

No additional research found