gene

IL15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for IL15 Gene

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🧬 Gene Info

Gene Symbol	IL15
Chromosome	4q31
Protein Type	Cytokine receptor
Function	IL-15 is a cytokine with diverse functions in both immune and nervous systems:
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where it
Molecular Weight	17 kDa
Pathways	PI3K, MAPK, NF-κB
NCBI Gene ID	3600
GeneCards	IL15
Human Protein Atlas	IL15
NK cell development and maintenance	IL-15 is essential for the survival, proliferation, and cytotoxic function of NK cells[@kennedy2000]
Memory CD8+ T cell homeostasis	IL-15 supports the maintenance of memory CD8+ T cells independent of antigen[@schluns2000]
NKT cell development	Critical for NKT cell development and function
Neuroprotection	IL-15 exhibits neuroprotective properties in models of Parkinson's disease and ALS through anti-apoptotic mechanisms[@panga2019]
Neuroinflammation	Modulates microglial activation and cytokine production
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL15 Gene

gene · 653 words

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Pathway Diagram

graph TD
    IL15["IL15 Gene"]
    IL15_protein["IL15 Protein"]
    IL15RA["IL15 Receptor Alpha"]
    IL2RB["IL2 Receptor Beta"]
    IL2RG["IL2 Receptor Gamma"]
    JAK1["JAK1"]
    JAK3["JAK3"]
    STAT5["STAT5"]
    NK_cells["NK Cells"]
    CD8_T["CD8+ T Cells"]
    microglia["Microglia"]
    neuroinflam["Neuroinflammation"]
    cytotoxicity["Cytotoxic Response"]
    neurodegen["Neurodegeneration"]
    neuroprotect["Neuroprotection"]
    BBB["Blood-Brain Barrier"]

    IL15 -->|"encodes"| IL15_protein
    IL15_protein -->|"binds"| IL15RA
    IL15_protein -->|"trans-presentation"| IL2RB
    IL2RB -->|"associates with"| IL2RG
    IL15RA -->|"activates"| JAK1
    IL2RB -->|"activates"| JAK3
    JAK1 -->|"phosphorylates"| STAT5
    JAK3 -->|"phosphorylates"| STAT5
    STAT5 -->|"activates"| NK_cells
    STAT5 -->|"promotes survival"| CD8_T
    IL15_protein -->|"activates"| microglia
    NK_cells -->|"mediates"| cytotoxicity
    CD8_T -->|"contributes to"| cytotoxicity
    microglia -->|"promotes"| neuroinflam
    cytotoxicity -->|"damages"| neurodegen
    neuroinflam -->|"leads to"| neurodegen
    IL15_protein -->|"may promote"| neuroprotect
    neuroinflam -->|"disrupts"| BBB

    style IL15 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style IL15_protein fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px
    style neuroprotect fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    style neurodegen fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style neuroinflam fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style cytotoxicity fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    style STAT5 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style JAK1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    style JAK3 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px

Outgoing (1)

Target	Relation	Type	Str
Stevens-Johnson Syndrome	biomarker_for	disease	0.75

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL15 in their description or question text

No additional research found