protein

IKBALPHA

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about IKBALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	IKBALPHA
Function	IκBα (Inhibitor of NF-κB α, encoded by NFKBIA) is the prototypical member of the IκB family of proteins, serving as the primary cytoplasmic inhibitor of the NF-κB transcription factor.
Primary Expression	Ubiquitous, inducible
Subcellular Localization	signals
Molecular Weight	36 kDa
Amino Acids	317 aa
GeneCards	IKBALPHA
Human Protein Atlas	IKBALPHA
N-terminal region	Contains the signal-response domain with serine residues (Ser32, Ser36) that are phosphorylated by the IKK complex
Ankyrin repeat domain (ARD)	Six tandem repeats form the NF-κB-binding surface; masks the nuclear localization signal (NLS) of RELA and p50
C-terminal PEST region	Proline-glutamic acid-serine-threonine-rich region involved in basal turnover and regulatory protein interactions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IκBα Protein

protein · 974 words

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Pathway Diagram

graph TD
    IKBALPHA["IKBALPHA"]
    neurodegeneration["neurodegeneration"]
    IKBALPHA -->|"implicated_in"| neurodegeneration
    style IKBALPHA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning IKBALPHA in their description or question text

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