| Gene Symbol | IKBALPHA |
| Function | IκBα (Inhibitor of NF-κB α, encoded by NFKBIA) is the prototypical member of the IκB family of proteins, serving as the primary cytoplasmic inhibitor of the NF-κB transcription factor. |
| Primary Expression | Ubiquitous, inducible |
| Subcellular Localization | signals |
| Molecular Weight | 36 kDa |
| Amino Acids | 317 aa |
| GeneCards | IKBALPHA |
| Human Protein Atlas | IKBALPHA |
| N-terminal region | Contains the signal-response domain with serine residues (Ser32, Ser36) that are phosphorylated by the IKK complex |
| Ankyrin repeat domain (ARD) | Six tandem repeats form the NF-κB-binding surface; masks the nuclear localization signal (NLS) of RELA and p50 |
| C-terminal PEST region | Proline-glutamic acid-serine-threonine-rich region involved in basal turnover and regulatory protein interactions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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