Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IDO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Kynurenine Pathway | activates | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 39287867 | induces | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Exposed amyloidogenic segments (β-sheet propensity residues) | 0.790 | protein biochemistry | Do chaperones selectively recognize path |
| Pharmacological P2RY12 inhibition (ticagrelor/clopidogrel) a | 0.583 | neurodegeneration | How does P2RY12-mediated VSMC dysfunctio |
| Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Def | 0.580 | neurodegeneration | How does gut microbiome dysbiosis contri |
| Amyloidogenic segments undergo conformational templating by | 0.380 | protein biochemistry | Do chaperones selectively recognize path |
| HSP70 recognition of exposed β-sheet segments triggers CHIP- | 0.380 | protein biochemistry | Do chaperones selectively recognize path |
| HSP90-CDC37 complex recognizes exposed hydrophobic clusters | 0.380 | protein biochemistry | Do chaperones selectively recognize path |
| Exposed amyloidogenic segments trigger CHIP-mediated oligome | 0.380 | protein biochemistry | Do chaperones selectively recognize path |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IDO in their description or question text
Score: 0.380 · protein biochemistry · 2026-04-27
The HSP90-CDC37 chaperone complex functions as a specialized surveillance system that recognizes amyloidogenic protein s
Score: 0.380 · protein biochemistry · 2026-04-27
This hypothesis proposes that HSP70's recognition of exposed β-sheet propensity sequences in amyloidogenic proteins serv