Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| NADPH Generation | mediates | process | 0.85 |
| Gene Expression | regulates | process | 0.85 |
| NADPH Production | associated_with | process | 0.85 |
| Redox Balance | associated_with | process | 0.80 |
| Anaplerosis | associated_with | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem | 0.646 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Clinical outcome analysis based on IDH mutation status | clinical | gliomas | 0.850 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresista [PMID:36637036] | Shigeta K, Hasegawa M, Hishiki T, Naito | EMBO J | 2023 | 1 |
| Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydr [PMID:31131326] | Tommasini-Ghelfi S, Murnan K, Kouri FM, | Sci Adv | 2019 | 1 |
| Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcino [PMID:28622513] | Cancer Genome Atlas Research Network. El | Cell | 2017 | 1 |
| Diagnostic, prognostic and predictive relevance of molecular markers in gliomas. [PMID:25944653] | Brandner S, von Deimling A | Neuropathol Appl Neurobiol | 2015 | 1 |
| IDH1 and IDH2 mutations in gliomas. [PMID:19228619] | Yan H, Parsons DW, Jin G, McLendon R, Ra | N Engl J Med | 2009 | 1 |
| Advancements in targeted therapies for acute myeloid leukemia. [PMID:41576755] | Connor MP, Barsouk A, Elghawy O, Lai C | Curr Opin Pharmacol | 2026 | 0 |
| ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clea [PMID:41637546] | Koh J, Liao C, Ng MSW, Hong JH, Heng HL | Cancer Res | 2026 | 0 |
| Serine mediates protection against calcium oxalate nephrolithiasis by attenuatin [PMID:41930872] | Yan X, Li G, Wang Z, Li C, Shi Y et al. | Int Immunopharmacol | 2026 | 0 |
| Chemical Proteomics Reveals Human Off-Targets of Fluoroquinolone Induced Mitocho [PMID:39964703] | ["Reinhardt T", "El Harraoui Y", "Rothem | Angewandte Chemie (Internation | 2025 | 0 |
| Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated ma [PMID:40203081] | Lu S, Li J, Li Y, Liu S, Liu Y, Liang Y, | Science translational medicine | 2025 | 0 |
| Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restrainin [PMID:38171332] | Si X, Shao M, Teng X, Huang Y, Meng Y, W | Cell metabolism | 2024 | 0 |
| Metabolic dysregulation and emerging therapeutical targets for hepatocellular ca [PMID:35256934] | Du D, Liu C, Qin M, Zhang X, Xi T, Yuan | Acta pharmaceutica Sinica. B | 2022 | 0 |
| Opportunities and obstacles for deep learning in biology and medicine. [PMID:29618526] | ["Ching T", "Himmelstein D", "Beaulieu-J | Journal of the Royal Society, | 2018 | 0 |
| Autophagy mediates degradation of nuclear lamina. [PMID:26524528] | ["Dou Z", "Xu C", "Donahue G", "Shimi T" | Nature | 2015 | 0 |
| Loop-based multiple heart-cutting two-dimensional liquid chromatography for targ [PMID:25897943] | ["Pursch M", "Buckenmaier S"] | Analytical chemistry | 2015 | 0 |
| Methanesulfonic acid sodium salt protects retina from acute light damage in mice [PMID:22882854] | Wang HY, Gu Q, Xu X | Chinese medical journal | 2012 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning IDH in their description or question text
No additional research found