Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Hypocretin/orexin wakefulness signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| HCRT | participates_in | gene | 0.42 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hypocretin-Neurogenesis Coupling Therapy | 0.688 | neurodegeneration | Sleep disruption as cause and consequenc |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Brainstem Circuit Modulation for PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Stem Cell Therapy for Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Sleep and Respiratory Network Interaction in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408] | Cappell SD, Mark KG, Garbett D, Pack LR, | Nature | 2018 | 1 |
| Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244] | Mugabo Y, Zhao S, Lamontagne J, Al-Mass | J Biol Chem | 2017 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861] | Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa | Brain Res | 2010 | 1 |
| Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165] | Dussor G, Koerber HR, Oaklander AL, Rice | Brain Res Rev | 2009 | 1 |
| Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces [PMID:38123729] | Bandarabadi M, Li S, Aeschlimann L, Colo | Molecular psychiatry | 2024 | 0 |
| Fresh versus frozen embryo transfers in assisted reproduction. [PMID:33539543] | ["Zaat T", "Zagers M", "Mol F", "Goddijn | The Cochrane database of syste | 2021 | 0 |
| Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530] | ["Gerasimaviciute V", "B\u00fcltmann U", | Injury prevention : journal of | 2020 | 0 |
| Circuit interrogation in freely moving animals. [PMID:30573821] | Wallace Damian J; Kerr Jason N D | Nature methods | 2019 | 0 |
| Get Ready for Another HIT: Health Information Technology and Information Transpa [PMID:31058787] | Christopher M Horvat; Robert Bart | Pediatric critical care medici | 2019 | 0 |
| Diabetic neuropathy. [PMID:31197153] | ["Feldman E", "Callaghan B", "Pop-Busui | Nature reviews. Disease primer | 2019 | 0 |
| Views and experiences with regard to antibiotic use of hospitalized patients in [PMID:29777924] | ["Zanichelli V", "Monnier A", "Tebano G" | Clinical microbiology and infe | 2019 | 0 |
| [ [PMID:30543234] | ["Isaac-Oliv\u00e9 K", "Ocampo-Garc\u00e | Nanoscale | 2019 | 0 |
| Spatial and temporal heterogeneity of mouse and human microglia at single-cell r [PMID:30760929] | ["Masuda T", "Sankowski R", "Staszewski | Nature | 2019 | 0 |
| Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. [PMID:29425372] | Olsson M, Ärlig J, Hedner J, Blennow K, | Sleep | 2018 | 0 |
| Human hippocampal neurogenesis drops sharply in children to undetectable levels [PMID:29513649] | ["Sorrells S", "Paredes M", "Cebrian-Sil | Nature | 2018 | 0 |
| A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Mod [PMID:29805100] | Borniger JC, Walker Ii WH, Surbhi, Emmer | Cell metabolism | 2018 | 0 |
| Environmental Surveillance of Norovirus Genogroups I and II for Sensitive Detect [PMID:28213546] | ["Kazama S", "Miura T", "Masago Y", "Kon | Applied and environmental micr | 2017 | 0 |
| Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olso [PMID:28159567] | ["Saer R", "Stadnytskyi V", "Magdaong N" | Biochimica et biophysica acta. | 2017 | 0 |
| Atmospheric pressure mass spectrometric imaging of live hippocampal tissue slice [PMID:29235455] | ["Kim J", "Seo E", "Kim H", "Park J", "L | Nature communications | 2017 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Hypocretin/orexin wakefulness signaling in their description or question text
No additional research found