Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Heat shock protein / proteostasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 | 0.820 | neurodegeneration | What is the therapeutic window between i |
| Chaperone-Mediated APOE4 Refolding Enhancement | 0.680 | neurodegeneration | APOE4 structural biology and therapeutic |
| Heat Shock Protein 70 Disaggregase Amplification | 0.668 | neurodegeneration | TDP-43 phase separation therapeutics for |
| HSP90-Tau Disaggregation Complex Enhancement | 0.634 | neurodegeneration | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Biochemical binding assays measuring PROTAC selectivity for APO | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| s:** - Dose-response studies showing therapeutic window without toxici | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| ApoE4 Function in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $360,000 |
| Down Syndrome Alzheimer's Disease: Mechanisms and Therapeutic Timing | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Metal Ion Homeostasis Dysregulation in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Prion Strain Diversity and Selective Vulnerability in CJD | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
| Experiment Validation: In vitro ThT Assay | validation | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Viral Infections and Alzheimer's Disease — causal mechanisms and thera | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress [PMID:40066224] | Liu H, Zhou Y, Wang Z, Liu D, Li Y, Lai | MedComm (2020) | 2025 | 1 |
| From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in [PMID:37643058] | Ghosh S, Vashisth K, Ghosh S, Han SS, Bh | J Biomol Struct Dyn | 2024 | 1 |
| Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteom [PMID:37652020] | Yuan S, Xu F, Li X, Chen J, Zheng J, Man | Cell Rep Med | 2023 | 1 |
| Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancie [PMID:19821156] | Molvarec A, Tamási L, Losonczy G, Madách | Cell Stress Chaperones | 2010 | 1 |
| Integrating NHANES and network toxicology to assess the impact of organophosphat [PMID:41804832] | Dai K, Huang Y, Cai H, Zhong G, Xie Z, W | Toxicology mechanisms and meth | 2026 | 0 |
| Crystal structures reveal phosphorylation-dependent disruption of the heat shock [PMID:41833837] | Stewart M, Paththamperuma C, McCann C, C | Cell stress & chaperones | 2026 | 0 |
| Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbat [PMID:41725010] | Wen M, Li J, Li Y, Hun M, Yang T, Meng Y | Cell & bioscience | 2026 | 0 |
| Single-cell transcriptomics reveal heat shock protein dysregulation in severe SA [PMID:41772029] | Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iw | Scientific reports | 2026 | 0 |
| Heat shock suppresses the innate immune response of bovine endometrial epithelia [PMID:41665179] | Tariq A, Sagheer M, Seekford ZK, Ren J, | Reproduction & fertility | 2026 | 0 |
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X et a | Autophagy | 2025 | 0 |
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X, Li | Autophagy | 2025 | 0 |
| Single nucleus RNA sequencing profile analysis to reveal cell type specific comm [PMID:40715263] | Pappu MAA, Alamin M, Sultana MH | Sci Rep | 2025 | 0 |
| Downregulation of NEAT1 due to loss of TDP-43 function exacerbates motor neuron [PMID:40661327] | Kawakami Y, Iguchi Y, Li J | Brain Commun | 2025 | 0 |
| Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel target [PMID:40319428] | ["Mohamed R", "Abdallah D", "El-Abhar H" | Inflammopharmacology | 2025 | 0 |
| Magnetothermal-activated gene editing strategy for enhanced tumor cell apoptosis [PMID:39080645] | ["Li M", "Li S", "Guo Y", "Hu P", "Shi J | Journal of nanobiotechnology | 2024 | 0 |
| Echocardiography Versus Magnetic Resonance Imaging Quantification and Novel Algo [PMID:37890567] | ["Wang T", "Reyaldeen R", "Akyuz K", "Po | The American journal of cardio | 2024 | 0 |
| Integrating network pharmacology and drug side-effect data to explore mechanism [PMID:38308871] | ["Tang M", "Wu Z", "Li F"] | Computers in biology and medic | 2024 | 0 |
| Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 [PMID:39883516] | Liu S, Li L, Liang Y, Tan Y, Wang X, Fen | Briefings in bioinformatics | 2024 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Curr Neuropharmacol | 2022 | 0 |
| Is targeting angiotensin-converting enzyme 2 (ACE2) a prophylactic strategy agai [PMID:36567123] | ["Li J", "Yan Y", "Dou F", "Gao J"] | Bioscience trends | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
closed · Rounds: 4 · Score: 0.89 · 2026-04-06